Author's response to reviews Title: LOH at 6q and 10q in Fractionated Circulating DNA of Ovarian Cancer Patients is Predictive for Tumor Cell Spread and Overall Survival Authors:
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منابع مشابه
Loss of heterozygosity at tumor suppressor genes detectable on fractionated circulating cell-free tumor DNA as indicator of breast cancer progression.
PURPOSE LOH on circulating DNA may provide tumor-specific information on breast cancer. As identification of LOH on cell-free DNA is impeded by the prevalence of wild type DNA in blood of cancer patients, we fractionated plasma DNA, and determined the diagnostic and prognostic value of both fractions. EXPERIMENTAL DESIGN Our cohort of 388 patients with primary breast cancer before chemotherap...
متن کاملAuthor's response to reviews Title: Loss-of-heterozygosity on chromosome 19q in early-stage serous ovarian cancer is associated with recurrent disease Authors:
Background: Ovarian cancer is a heterogeneous disease and prognosis for apparently similar cases of ovarian cancer varies. Recurrence of the disease in early stage (FIGO-stages I-II) serous ovarian cancer results in survival that is comparable to those with recurrent advanced-stage disease. The aim of this study was to investigate if there are specific genomic aberrations that may explain recur...
متن کاملLoss of heterozygosity and microsatellite instability as predictive markers among Iranian esophageal cancer patients
Objective(s): Variation in microsatellite sequences that are dispersed in the genome has been linked to a deficiency in cellular mismatch repair system and defects in several genes of this system are involved in carcinogenesis. Our aim in this study was to illustrate microsatellite DNA alteration in esophageal cancer. Materials and Methods: DNA was extracted from formalin fixed paraffin embedde...
متن کاملCase report: A Metastatic Transitional Cell Carcinoma of the Ovary
Background: Transitional cell carcinoma (TCC) is a rare type of ovarian epithelial cancer. This type of ovarian cancer accounts for only 1% of superficial epithelial carcinomas. Ovarian cancer is a major clinical challenge in obstetrics and gynecology. The reason of this is the lack of specific symptoms for ovarian cancer before the recurrence and progression of the tumor, so many cases are not...
متن کاملبررسی خصوصیات بالینی، آسیبشناسی و نتایج درمانی تومورهای بدخیم استرومای طناب جنسی تخمدان
Background: Ovarian sex cord-stromal tumors (SCST) account for rare ovarian malignancy. These tumors are 5-8% of all ovarian neoplasms. The most common type of sex cord ovarian tumors is granulosa cell tumor (GCT). In this study our purpose was to have a look at some of clinicopathologic aspects and treatment results of these tumors. Methods: In a retrospective study, all documents of patients ...
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